Birmingham vs. Norwich (Tuesday, 7.00pm)
While the Canaries are well placed to earn promotion to the Premier League, Blues needed a 1-0 win at Sheffield Wednesday at the weekend to move out of the relegation zone.
We say: Birmingham City 0-2 Norwich City
Having got an important three points on the board at the weekend, Karanka will feel that some pressure has been lifted ahead of this game. However, despite the opportunity to play with more freedom, we still expect the visitors to record a comfortable win at St Andrew's.
Derby vs. Huddersfield (Tuesday, 7.00pm)
While the Rams and Terriers occupy 18th and 19th position respectively, Rotherham United having matches in hand means that neither side can afford any complacency if they want to avoid a relegation battle.
We say: Derby County 2-1 Huddersfield Town
Ahead of such an important fixture, both teams will set out to claim what could prove to be a season-defining three points come the end of the season. While the visitors will be on a high after the weekend, we expect Derby to show their extra quality in the final third over the course of the 90 minutes.
Middlesbrough vs. Bristol City (Tuesday, 7.00pm)
Eighth-placed Boro are currently three points behind the top six, while the Robins' horrific recent run of form has left them in 15th position.
We say: Middlesbrough 2-0 Bristol City
Luton vs. Millwall (Tuesday, 7.45pm)
The Lions, who sit 11th in the table, have not lost in their last eight league games, the longest current streak of any side in the division.
We say: Luton Town 0-1 Millwall
Rotherham vs. Nott'm Forest (Tuesday, 7.45pm)
The Reds are currently in 17th, seven points ahead of the Millers, who occupy the final spot in the bottom three in 22nd.
We say: Rotherham United 0-1 Nottingham Forest
Wycombe vs. Reading (Tuesday, 7.45pm)
While the visitors have lost three of their most recent four fixtures, Wycombe sit 11 points adrift of safety despite earning a draw at Millwall on Saturday.
We say: Wycombe Wanderers 1-2 Reading
With wins only being good enough for Wycombe at this stage, we expect Ainsworth to instruct his players to go on the front foot. However, that may not be the right tactics against a team of Reading's quality, and the Royals could edge out their hosts in a competitive contest.