The Lions, who sit 11th in the table, have not lost in their last eight league games, the longest current streak of any side in the division.
Millwall had won three games in a row heading into their home game against bottom of the table Wycombe Wanderers on Saturday but drew 0-0 against the Chairboys to cool their playoff ambitions.
The match brought their 15th draw in the Championship this season – the most in the division – and leaves them seven points behind the top six; they have a potentially crucial meeting with 10th-placed Barnsley after their trip to Luton.
Only six sides in the second tier have picked up more points away from home than Millwall (23) this season and only three clubs have conceded fewer goals on the road than the Lions (14).
The impressive form has helped contribute to Gary Rowett's side having the fourth-best defence in the Championship this season, with only promotion-pushing Norwich City, Swansea City and Watford letting in fewer goals. Meanwhile, the goalless draw with Wycombe was Bartosz Bialkowski's 13th clean sheet – only Freddie Woodman has more.
It could be a tricky evening for Luton as the Hatters have scored just three goals in eight league games in 2021 – the fewest of any Championship side.
The home side are currently on a run of only three wins in their last 12 league matches, which has seen their own playoff hopes fall by the wayside. Nathan Jones's men are now 16th and closer to the bottom three (eight points) than they are to the top six (12 points).
The Bedfordshire side were beaten 3-0 by Stoke City on Saturday afternoon, ensuring a miserable return to the bet365 Stadium for Jones, and the Welshman described it as "our worst performance I have ever had as Luton manager".
The Hatters have not won against Millwall in their last eight attempts, meanwhile, last beating the Lions in 2005. The South London side comfortably won 2-0 in this season's reverse fixture in October and perhaps should have scored more.
Luton Town Championship form: LLDWLL
Luton Town form (all competitions): LLDWLL
Millwall Championship form: DDWWWD
Jones is likely to make changes after the Hatters' poor performance on Saturday, with George Moncur and Joe Morrell pushing to be named in the starting lineup, while there could be a first start for January signing Elijah Adebayo.
Luton Town possible starting lineup:
Sluga; Pearson, Cranie, Bradley, Potts; Moncur, Rea, Dewsbury-Hall; Cornick, Collins, Adebayo
Millwall possible starting lineup:
Bialkowski; Hutchinson, Pearce, Evans; Romeo, Woods, Kieftenbeld, Malone; Wallace, Bodvarsson, Bennett
We say: Luton Town 0-1 Millwall
Luton are struggling for form so a visit from a Millwall side that are tough to beat would not have been Jones's ideal fixture; neither team tend to net too many goals so we are predicting a low-scoring away win.
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