Napoli recovered from defeat to Sassuolo with a 2-1 victory in the Europa League over HNK Rijeka on Thursday night.
They trailed against the Croatian side, but Diego Demme drew them level with a tap in before an own goal from Filip Braut proved to be the decisive moment.
Attention now turns to making up ground in the league, as they sit five points behind early league leaders AC Milan.
Napoli average the most shots per game in Serie A (19) so the potential is there for a strong season for Gli Azzurri after a disappointing seventh place finish in 2019-20 – their lowest final position in 11 years.
They have not beaten Bologna in their last three attempts, but have happy memories from this fixture after winning 7-1 at Stadio Renato Dall'Ara in 2017 - their biggest-ever Serie A away win.
Bologna are unlikely to concede quite that many this time around, but the chances of them keeping a clean sheet seem pretty slim.
After letting in two goals against Cagliari last weekend, Sinisa Mihajlovic's side now hold the unwanted all-time record in Europe's top five leagues of conceding in 39 consecutive league games, surpassing MSV Duisburg's run of 38 matches in 1975.
The win lifted them to 13th in the table, but they are still only two points above the relegation zone heading into Sunday's game.
Bologna Serie A form: LWLLLW
Bologna form (all competitions): WLLLWW
Napoli Serie A form: WWLWWL
Napoli form (all competitions): WLWWLW
Sinisa Mihajlovic has rarely changed his starting lineup this season and could name the same XI for the second match in a row, particularly after victory over Cagliari.
Bologna possible starting lineup:
Skorupski; Silvestri, Danilo, Tomiyasu, Hickey; Schouten, Svanberg; Orsolini, Soriano, Barrow; Palacio
Napoli possible starting lineup:
Ospina; Lorenzo, Manolas, Koulibaly, Hysaj; Ruiz, Bakayoko; Lozano, Mertens, Insigne; Osimhen
We say: Bologna 1-3 Napoli
Based on Bologna's poor defensive record, Napoli's talented frontline could come into their own on Sunday. Gattuso's side should claim victory, but Bologna are also in good scoring form, so a clean sheet seems unlikely for either team.