Winger Junior Stanislas picked up a hamstring problem during the midweek Sky Bet Championship win over Swansea, while midfielder Jefferson Lerma is suspended after collecting two yellow cards earlier in the competition.
On-loan Saints forward Shane Long is cup-tied, while defenders Adam Smith (ankle) and Lloyd Kelly (adductor) and midfielder David Brooks (ankle) are also not fit. Lewis Cook is ruled out for the season with a knee injury.
Southampton forward Takumi Minamino is cup-tied having already featured for parent club Liverpool.
Bournemouth (provisional squad): Begovic, S Cook, Stacey, Carter-Vickers, Rico, Riquelme, Wilshere, Pearson, Billing, Solanke, Groeneveld, Travers, Mepham, Zemura, Kilkenny, Saydee, Surridge, Anthony, O'Connell, Burchall
Southampton (provisional squad): Forster, Walker-Peters, Bertrand, Vestergaard, Bednarek, Ward-Prowse, Armstrong, Diallo, Adams, N'Lundulu, Tella, McCarthy, Stephens, Salisu, Redmond, Djenepo, Ramsay, Watts, Ferry, Pearce