Sportiello was soon called into action again minutes later to keep out Dybala's low strike.
Juventus finally made their pressure count in the 28th minute as Dybala fired a swerving effort from outside the box into the roof of the net.
The Argentine almost grabbed his second goal of the match on the stroke of half time, but his close-range attempt was stopped by the keeper.
However, Juventus did manage to double their lead four minutes into the second half as Mandzukic arrived inside the six-yard box to guide home Dybala's low cross.
Dybala soon came close to giving Juventus a three-goal lead when he curled a free kick inches wide, before the Argentine was denied by a one-handed save from Sportiello.
Any hopes that the visitors had of producing an unlikely comeback were dealt a major blow in the 73rd minute as Rafael Toloi was dismissed for picking up his second yellow card of the match.
However, the failed spot kick mattered little as the Old Lady comfortably held on to take the three points and continue their rise up the table following a shaky start to the season. body check tags ::