Lyon coach Remi Garde has made three changes to his side following their loss at Ajaccio on Wednesday.
Gueida Fofana, Steed Malbranque and Alexandre Lacazette have all been dropped, with Mehdi Zeffane, Arnold Mvuemba and Nabil Fekir coming into the team.
Meanwhile, Lille boss Rene Girard has opted for two alterations to the team that beat Evian TG on Tuesday.
Djibril Sidibe and Soualiho Meite have been replaced by Pape Souare and Antonio Mavuba.
Lyon: Lopes, Zeffane, Kone, Umtiti, Bedimo, Gonalons, Mvuemba, Grenier, Briand, Gomis, Fekir
Lille: Enyeama, Basa, Beria, Kjaer, Souare, Balmont, Gueye, Martin, Mavuba, Kalou, Roux