Pep Guardiola's men sit at the top of Group A with nine points to their name - one point clear of the second-placed Parisiens - and here Sports Mole rounds up the team news for both clubs.
Doubtful: Jack Grealish (knock)
Sports Mole's predicted XI: Ederson; Walker, Dias, Laporte, Cancelo; Silva, Rodri, Gundogan; Mahrez, Jesus, Foden
Doubtful: Gianluigi Donnarumma (illness)
Sports Mole's predicted XI: Navas; Hakimi, Marquinhos, Kimpembe, Mendes; Verratti, Gueye, Wijnaldum; Messi, Mbappe, Neymar