Spurs have won 15 of their last 18 outings across all competitions, including all three so far in 2019 without conceding.
Here, Sports Mole looks at how they could line up against the Red Devils.
Pochettino named a near-full strength side for the midweek EFL Cup win over Chelsea, and he is unlikely to make too many changes for this match.
The in-form Son Heung-min is expected to lead the line in what will be his final game before joining up with South Korea at the Asian Cup.
There is also an outside chance that Eric Dier could return to the squad following surgery to remove his appendix last month, while Jan Vertonghen is also closing in on a comeback and Lucas Moura will be assessed before kickoff.
Mousa Dembele could also be in contention following an ankle injury, although the possibility of a January move to China could mean that he has played his final game for the club.