Kike partners Patrick Bamford up front for Middlesbrough as they travel to Rotherham United in the Championship this afternoon.
Yanic Wildschut also makes a start for the visitors, who are looking to consolidate their position in the playoff places.
Meanwhile club-record signing Jonson Clarke-Harris starts for the Millers alongside Alex Revell up top.
Rotherham: Collin; Richardson, Morgan, Arnason, Braodfoot; Taylor, Green, Frecklington, Pringle; Revell, Clarke-Harris
Middlesbrough: Konstantopoulos; Nsue, Ayala, Gibson, Friend; Reach, Clayton, Leadbitter, Wildschut; Kike, Bamford.