Meanwhile, managerless Port Vale will be hoping to end their six-game winless run as they look to boost their survival hopes.
Peterborough's hope of achieving promotion have been dented by a four-game winless league run, which began with a goalless draw against Lincoln City last month.
Posh have ultimately failed to collect a point since that result, having lost three consecutive league matches to Wigan Athletic, Exeter City and Wycombe Wanderers.
After conceding three goals before the hour mark in Saturday's away clash with Wycombe, Peterborough showed signs of mounting a fightback when David Ajiboye and Ricky-Jade Jones grabbed a goal apiece.
However, Wycombe added two more goals to their tally to condemn Peterborough to a disappointing 5-2 defeat, leaving them in fifth position and four points adrift of the top two.
With Posh desperate to claim all three points on Tuesday, they can take confidence from the fact that they have won each of their last four meetings with Port Vale.
Port Vale are currently searching for a permanent manager after Andy Crosby was relieved of his duties following a 3-0 defeat to Fleetwood Town earlier this month.
They would have been grateful to salvage a point from Saturday's away meeting with Stevenage after Funso Ojo netted a 98th-minute penalty to ensure that his side took a share of the spoils.
Despite picking up a point at the weekend, the Valiants were unable to escape the drop zone, with goal difference keeping them below 21st-placed Port Vale.
After failing to win any of their last five meetings with Posh (D1, L4), the Valiants will enter Tuesday's encounter with the aim of clinching their first win over Peterborough since September 2016.
Kwame Poku is set to return to the matchday squad, having been forced to miss the last seven matches through injury.
Winger Michael Olakigbe may be brought straight back into the starting lineup after serving a one-match suspension.
Ryan Loft is also a doubt for the midweek fixture after the forward sat out Saturday's draw with Stevenage due to illness.
Buoyed from scoring a late equaliser at the weekend, Ojo is expected to make his third consecutive start since returning from injury earlier this month.
Peterborough United possible starting lineup:
Bilokapic; Katongo, Knight, Edwards; Burrows; Kyprianou, Collins; Ajiboye, Randall, Olakigbe; Jade-Jones
Port Vale possible starting lineup:
Ripley; Lopata, Smith, Debrah; Massey, Ojo, Lowe, Grant; Chislett, Weir; Wilson
We say: Peterborough United 2-1 Port Vale
After losing their last three matches, Peterborough will view Tuesday's contest as an opportunity to return to winning ways against a struggling Port Vale side, and we think that Posh will ultimately do enough to claim a narrow victory.
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