The hosts have lost to Hellas Verona and Spezia Calcio thus far, whereas Roma stole a point against Juventus after suffering a defeat of their own to Verona.
A home fixture against newly-promoted Spezia Calcio, on paper, would appear to be a routine three points for Udinese, but Le Zebrette suffered a dismal defeat to the visitors in midweek.
Spezia's Andrej Galabinov bagged a brace to inflict a second defeat in as many matches upon Udinese, who are one of only five teams without a point on the board after two games of the 2020-21 campaign.
Luca Gotti's men had the advantage of an extra man for the final 25 minutes against Spezia but were unable to find a way through in the dying embers of the game, leaving Udinese fans extremely frustrated at their poor start to the season.
A fixture against Italian giants Roma would not seem to do Udinese any favours in their bid to turn their fortunes around, but Paulo Fonseca's men are also winless since the new campaign kicked off.
While Roma are yet to register their first three points of the 2020-21 season, holding champions Juventus to a 2-2 draw is certainly a respectable result nonetheless.
Jordan Veretout and Cristiano Ronaldo both netted a brace for their respective sides - one each from the penalty spot - although Roma were unable to take advantage of Adrien Rabiot's sending-off just after the hour mark.
Juventus have not been their usual dominant selves over the past couple of months, but Fonseca's men will no doubt be satisfied with a point against the reigning champions as they bid to go one better this weekend.
However, Udinese did take the spoils in a 2-0 victory when the sides last faced off in July, although Roma stormed to a 4-0 win in the most recent meeting at the Dacia Arena and have won 12 of the last 14 matches between the two clubs.
Udinese Serie A form: LL
Roma Serie A form: LD
Udinese have re-signed Roberto Pereyra from Watford at a time where they are crying out for some impetus going forward, although the Argentine is lacking match fitness and will not be involved so soon.
Diego Perotti and Javier Pastore remain on the treatment table alongside long-term absentee Nicolo Zaniolo, while Federico Fazio is doubtful with an ankle sprain, but Fonseca is not expected to make wholesale changes for the trip to Udinese.
Udinese possible starting lineup:
Musso; Becao, Samir, De Maio; Ter Avest, Arslan, De Paul, Coulibaly, Ouwejan; Okaka, Lasagna
Roma possible starting lineup:
Mirante; Mancini, Kumbulla, Ibanez; Peres, Veretout, Pellegrini, Spinazzola; Pedro, Mkhitaryan; Dzeko
We say: Udinese 1-3 Roma
Udinese will be desperate to put things right following their painful defeat to Spezia, but they are coming up against a Roma side who are equally determined to get a first win of the season under their belts. The Giallorossi are historically strong in this fixture and boast a superior quality of players, so we are backing Fonseca's men to come out on top.