The Baggies have been in stuttering form of late but will see this fixture as an opportunity to build some momentum as they look to secure an automatic promotion spot.
West Brom's title charge has faltered in recent weeks, with the Baggies winless in their last seven Championship fixtures, losing three.
Slaven Bilic's side now find themselves just two points ahead of third-placed Nottingham Forest, having previously held a much more significant lead on the chasing pack.
However, their exploits earlier in the season have given them enough of a cushion that they still remain in an excellent position to secure automatic promotion, and they will view this fixture against Luton as a possible turning point.
Having already beaten the newly-promoted outfit 2-1 earlier this season, Bilic will hope his side can do the double over Saturday's opponents and use the fixture to restore morale and build momentum.
West Brom still boast the fiercest attack in the Championship and are the only side to have netted more than 50 goals so far in the division.
Luton, meanwhile, are bottom of the league and have by far the worst defensive record in the league, conceding 63 times in just 29 games so far - nine more than second-bottom side Barnsley.
Luton will be hoping to build on that result and capitalise on the Baggies' poor form to pull off a shock against West Brom.
West Bromwich Albion Championship form: DLDDLL
West Bromwich Albion form (all competitions): DWDLWL
Luton Town Championship form: DLLLLW
Luton Town form (all competitions): LLLLLW
West Brom boss Bilic has more or less a full squad to choose from, with just one senior player out injured.
Left-back Kieran Gibbs is a regular on the treatment table and he is expected to be out once again with a hamstring problem.
Luton head coach Jones, on the other hand, has a few more absentees to deal with.
West Bromwich Albion possible starting lineup:
Johnstone; O'Shea, Bartley, Ajayi, Ferguson; Livermore, Sawyers; Phillips, Krovinovic, Edwards; Robson-Kanu
Luton Town possible starting lineup:
Sluga; Bree, Daniels, Bradley, Potts; Ruddock, Rea, Tunnicliffe; Cornick, Collins, LuaLua
We say: West Bromwich Albion 2-0 Luton Town
Despite West Brom's woeful league form, they should still have enough quality to beat the side propping up the table, although it may be a closer contest than perhaps it should.
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