The Welsh outfit will enter the contest off the back of a 1-0 home defeat to Bradford City, while Sutton's struggles continued on Saturday afternoon with a 1-0 loss at Morecambe.
Sutton are playing in their third straight season in League Two, finishing eighth and 14th since earning promotion from the National League, but they are locked in a huge battle for survival this term.
The Yellows have only picked up 22 points from their 31 league matches this season courtesy of a record of four wins, 10 draws and 17 defeats, which has left them down in 23rd position in the table.
It is not quite time to hit the panic button, as the team are only seven points behind 22nd-placed Colchester United, but they have not managed to pick up all three points in League Two since Boxing Day.
Steve Morison's side will enter this match off the back of a 1-0 defeat at Morecambe, but they did pick up a point against Doncaster Rovers in their last game in front of their own fans on February 3.
Sutton have lost two of their last three games against Wrexham, meanwhile, including a 2-1 defeat in the reverse fixture in Wales earlier this season.
Wrexham's form is worrying, losing each of their last four matches in all competitions, including their last three in League Two against Newport County, Salford City and Bradford.
Phil Parkinson's side were also thumped 4-1 by Blackburn Rovers in the FA Cup at the end of January, with their last win proving to be a 2-0 success over AFC Wimbledon on January 13.
Wrexham's recent struggles have seen them drop into fifth position in the table, six points ahead of eighth-placed AFC Wimbledon in the battle for playoff positions.
The Welsh outfit are only two points behind third-placed Crewe Alexandra, so they are still in a strong position, and this could be the perfect match to get their season back on track.
The Red Dragons, who were taken over by Canadian-American actor Ryan Reynolds and American actor Rob McElhenney in late 2020, have only managed to win four of their 14 away league matches this season, but Sutton have the third-worst home record in League Two in 2023-24.
Sutton have not reported any fresh injury concerns for this match, with Morison expected to have the same squad available from the one that travelled to Morecambe.
Lee Angol has only managed to contribute two goals in the league this season, but the experienced striker is expected to continue in the final third of the field.
As for Wrexham, head coach Parkinson is expected to resist the temptation to shuffle his pack following the narrow home defeat to Bradford.
Parkinson is expected to stick with a back five for this contest, with Elliot Lee, who has come up with 13 league goals from a deeper area this season, featuring in the three-man midfield.
Sutton United possible starting lineup:
Bouzanis; Kizzi, Goodliffe, Hart; Jackson, Eastmond, Lain, Patrick; Angol, Duke-McKenna, Beautyman
Wrexham possible starting lineup:
Okonkwo; Barnett, Hayden, Tozer, O'Connell, McClean; Cannon, Evans, Lee; Marriott, Mullin
We say: Sutton United 0-1 Wrexham
There will be big pressure on Wrexham head coach Parkinson to deliver a positive result here, and we are expecting this to be a nervy affair. The Welsh outfit can call upon the superior quality, though, and we are backing them to navigate their way to an important three points.
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