Villarreal manager Unai Emery is expected to make a full 11 changes to his side for the second leg of their Champions League quarter-final with Bayern Munich at the Allianz Arena.
Boasting a 1-0 lead from the first leg, the Yellow Submarine continue to cope without long-term absentee Alberto Moreno, while Boulaye Dia may not shake off a muscle problem in time either.
Emery made significant alterations for the weekend's La Liga draw with Athletic Bilbao, and the first change for Tuesday will see Geronimo Rulli return in goal over Sergio Asenjo.
Pau Torres missed the league draw through suspension but is set to return to the rearguard alongside Raul Albiol here, with Serge Aurier and Aissa Mandi making way.
Mario Gaspar and Alfonso Pedraza are also set to be demoted by Juan Foyth and Pervis Estupinan, with the former seemingly shaking off an injury scare which forced him off late in the first leg.
Dani Parejo, Etienne Capoue and Francis Coquelin are all well-rested and ready to return to the engine room, while Giovani Lo Celso could operate just ahead of the trio.
Gerard Moreno squandered a number of opportunities to make the net ripple in the first leg, but Arnaut Danjuma's 14th goal of the season ensured that Villarreal would have the upper hand before the journey to Germany.
Villarreal possible starting lineup: Rulli; Foyth, Albiol, Torres, Estupinan; Parejo, Coquelin, Capoue; Lo Celso; Moreno, Danjuma
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