Borussia M'bach vs. Stuttgart (Saturday, 2.30pm)
Stuttgart, meanwhile, can move one point behind their forthcoming opponents in the table with a victory as they look to finish in the top half of the table in their first season back in the Bundesliga.
We say: Borussia Monchengladbach 3-1 Stuttgart
Gladbach have been strong at home lately, so given Stuttgart's mounting injury crisis, Rose's side really should be edging closer to a European qualification finish by winning here.
If Die Fohlen's attacking talent combine to their full potential, there should be no way Matarazzo's patched-up XI can live with them.
B. Leverkusen vs. Union Berlin (Saturday, 2.30pm)
A point would all but ensure that Leverkusen qualify for the Europa League, while Union Berlin need to win to be able to overtake Leverkusen on the final day of the campaign.
We say: Bayer Leverkusen 1-1 Union Berlin
We can envisage a closely fought affair, with Leverkusen ultimately getting the point which they will likely be looking for in order to take a huge step towards Europa League qualification.
Indeed, they have been much tougher to beat since Wolf replaced Peter Bosz as interim manager last month, while only four sides have lost fewer Bundesliga games than Union Berlin this season.
Hertha Berlin vs. FC Koln (Saturday, 2.30pm)
The home team, meanwhile, can secure their safety with a victory.
We say: Hertha Berlin 1-1 FC Koln
Koln have been stronger away from home this season, so we can envisage them gaining a positive result against a Hertha outfit whose injuries and congested schedule are likely to take its toll.
However, Dardai has made them much tougher to beat since his appointment in February, with a draw on Saturday representing a good result for Hertha.
Augsburg vs. Werder Bremen (Saturday, 2.30pm)
Markus Weinzierl's side suffered a 2-1 defeat to Stuttgart in their most recent outing, while Bremen managed to claim a point from a goalless draw with Bayer Leverkusen.
We say: Augsburg 2-2 Werder Bremen
Both sides will sense an opportunity to all but confirm their safety in the Bundesliga this weekend, and that should lead to an enthralling affair between two sides who otherwise flatter to deceive.
Weinzierl is still re-finding his feet at Augsburg, but the hosts should have no trouble breaching Bremen's leaky defence, although the visitors have the attacking talent needed to secure a point in this pivotal encounter.
Arminia Bielefeld vs. Hoffenheim (Saturday, 2.30pm)
The hosts held Hertha Berlin to a goalless stalemate in their most recent outing, while mid-table Hoffenheim enjoyed a comfortable win over Schalke 04.
We say: Arminia Bielefeld 1-1 Hoffenheim
Arminia have far more to play for than Hoffenheim do at this stage and are not going down without a fight, so we anticipate a close affair this weekend.
Despite a recent upturn in results, Hoffenheim continue to struggle for form away from home, and we can see Kramer's hosts doing enough to claim another point in the battle to avoid the drop.
Freiburg vs. Bayern (Saturday, 2.30pm)
The visitors, meanwhile, wrapped up a ninth successive Bundesliga title last weekend.
We say: Freiburg 1-4 Bayern Munich
With little at stake for either side, we expect Bayern to benefit from another open encounter.
While the Bavarians are unlikely to find Freiburg's defence as accommodating as Gladbach's last week, this could be the match in which Lewandowski sensationally breaks Muller's record for most goals scored in a Bundesliga season.
Schalke vs. Frankfurt (Saturday, 2.30pm)
With nothing but pride on the line for the hosts, already-relegated Schalke 04 prepare to take on Champions League-chasing Eintracht Frankfurt in Saturday's Bundesliga clash.
Dimitrios Grammozis's side lost 2-1 to Hertha Berlin in midweek, while Frankfurt's top-four aspirations suffered a blow with a 1-1 draw against Mainz 05 last week.
We say: Schalke 04 0-3 Eintracht Frankfurt
The sooner this season ends for Schalke the better, as the league's basement side continue to fall short almost every weekend and must look at how to rebuild from the 2021-22 season onwards.
Frankfurt have not been able to replicate their remarkable home form on the road throughout the season, but they should be too strong for Schalke as they bid to keep their Champions League hopes alive.