Left-back Erik Pieters could continue his run in the starting lineup after recovering from a knock in time to face the Magpies at Turf Moor.
The Dutchman was replaced in the first half of Burnley's 3-2 defeat at Southampton last weekend but has been able to shake off the knock to his upper leg and is in contention to play ahead of Charlie Taylor.
Right-back Phil Bardsley will also be back in the Burnley squad to face Newcastle after a family bereavement forced him to miss the last nine league games.
Striker Chris Wood, who has scored in each of his last three Premier League appearances, is set to lead the line once again alongside Matej Vydra, who scored his second top-flight goal of the season against the Saints last weekend.
Burnley possible starting XI: Pope; Lowton, Tarkowski, Mee, Pieters; Gudmundsson, Brownhill, Westwood, McNeil; Vydra, Wood
Watch the Sports Mole Football Shorts prediction for this game below:
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