Meanwhile, Derby head into this contest sitting eight points clear of the relegation zone courtesy of their 2-0 win over Luton Town.
Still sitting in the top six with seven matches remaining, Veljko Paunovic will be satisfied with Reading's position heading into the Championship run-in.
Nevertheless, the Royals have now gone four games without a win, a period which cannot be prolonged if they want to earn a return to the Premier League.
Having conceded a lead against Barnsley on Friday evening in a game which also saw Lucas Joao miss an open goal, there will be frustration within the Reading camp ahead of their meeting with the Rams.
The fixtures also get no easier for this squad with games at Norwich City and Watford to be played either side of a home fixture against Swansea City.
On a positive note, Reading have scored in their last seven matches, goals which have been required with four games passing by without a clean sheet.
As far as Derby are concerned, Wayne Rooney breathed a sigh of relief on Friday as his side comfortably got the better of mid-table Luton Town.
Seven outings without success had put the East Midlands outfit under pressure in their battle to avoid a drop, particularly with Rotherham United still possessing four games in hand.
Only returning 43 points from 39 fixtures means that there is still much work ahead to avoid dropping into the third tier, but Rooney will at least feel content that Derby have established some distance between themselves and the chasing pack.
Michael Morrison is expected to miss out for Reading after suffering a recurrence of a hamstring injury at Oakwell.
Thomas Holmes should deputise for the veteran in the centre of defence, while Paunovic must decide whether to drop Joao on the back of a return of just one goal in nine outings.
Martyn Waghorn and Gregory are unlikely to feature for Derby after suffering hamstring injuries versus Luton.
Reading possible starting lineup:
Cabral; Yiadom, Holmes, Moore, Gibson; Rinomhota, Laurent; Meite, Olise, Ejaria; Joao
Derby County possible starting lineup:
Marshall; Wisdom, Clarke, Forsyth; Byrne, Bird, Shinnie, Buchanan; Sibley, Jozwiak; Kazim-Richards
We say: Reading 2-1 Derby County
Having defeated Luton on Good Friday, Rooney and his squad will feel that they can perform with an extra degree of freedom. However, that may work against them, and we feel that the Royals have enough quality in the final third to edge this contest by the odd goal in three.
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