Roma have made just one change to the side which drew 4-4 against Bayer Leverkusen in midweek to face Fiorentina in Serie A.
After coming on in the final five minutes against Leverkusen, former Manchester City striker Edin Dzeko has replaced defender Vassilis Torosidis in Rudi Garcia's starting lineup.
As for the home side, head coach Paulo Sousa has made a number of changes to the side which lost 2-1 at home to Lech Poznan in the Europa League in midweek.
Ciprian Tatarusanu, Gonzalo Rodriguez, Milan Badelj, Matias Vecino, Federico Bernardeschi, Jakub Błaszczykowski, Borja Valero and Nikola Kalinic come into the starting XI in a huge change up for the Viola.
Fiorentina: Tatarusanu; Roncaglia, Rodriguez, Astori; Badelj, Vecino, Bernardeschi, Blaszcykowski, Valero; Kalinic, Ilicic
Roma: Szczesny; Florenzi, Manolas, Rudiger, Digne; Pjanic, De Rossi, Nainggolan; Gervinho, Dzeko, Salah
