As missing out on the Champions League remains a real possibility for both sides, they will at least have few absentees for one of Calcio's traditional heavyweight clashes.
Here, Sports Mole rounds up the latest team news for the two clubs.
Doubtful: Merih Demiral (thigh)
Sports Mole's predicted XI: Szczesny; Danilo, De Ligt, Chiellini, Sandro; Cuadrado, Bentancur, Rabiot, Chiesa; Morata, Ronaldo
Sports Mole's predicted XI: Donnarumma; Calabria, Kjaer, Tomori, Hernandez; Kessie, Bennacer; Saelemaekers, Calhanoglu, Rebic; Ibrahimovic
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