Meanwhile, the hosts seek to put last week's defeat behind them, which saw their five-game unbeaten run come to an end.
Sparta failed in their quest to pick up two wins on the bounce as they were defeated 2-0 by AZ Alkmaar at the AFAS Stadion on Saturday.
De Kasteelheren have now dropped to 11th place in the standings, three points away from the top half with five games left to play.
A victory for them this weekend would complete a league double over their visitors after a 1-0 win in last month's reverse fixture.
Saturday's hosts have a strong record in this fixture, unbeaten in the last seven games on home turf between the teams dating back to 2009.
VVV'S downward spiral continued as they suffered a 10th league defeat on the trot following a 2-0 loss to PSV Eindhoven on Sunday.
The Yellow Black Army are still in the drop zone, albeit only on goal difference, but with time running out, an upturn in form is needed.
Only two goals have been scored by Saturday's visitors in the last five games, which is surprising for a team with the league's leading goalscorer.
If they are to hold on to their top-flight status for another year, then Giorgos Giakoumakis has to rediscover his touch in front of goal.
Christos Donis misses out for the fifth match in a row due to a muscle injury which he sustained in the middle of March.
Meritan Shabani is also expected to sit the game out as the 22-year-old remains on the sidelines with a groin problem.
The hosts will have to make do with the absence of 29-year-old Tim Coremans, who has missed the last nine months of action due to a shoulder problem.
Bart Vriends recently picked up a thigh injury in the last week of March, and he is expected to miss the clash as he is yet to recover.
Sparta Rotterdam possible starting lineup:
Okoye; Abels, Heylen, Beugelsdijk, Fortes; Auassar, Burger, Smeets; Duarte, Mijnans, Thy
VVV-Venlo possible starting lineup:
Kirschbaum; Dekker, Da Graca, Gelmi, Pachonik; Linthorst, Janssen, Schafer, Machach; Van Crooy, Giakoumakis
We say: Sparta Rotterdam 2-1 VVV-Venlo
VVV's poor run of form does not look like coming to an end any time soon, as they have looked short of confidence in recent matches. While we expect the visitors to push their hosts all the way, we are backing Sparta to claim all three points.
body check tags ::