While the visitors do not feature in the automatic promotion race, the Royals will progress into fourth position in the Championship standings by claiming maximum points at Vicarage Road.
However, with Brentford and Swansea City both failing to take advantage, the Hornets effectively strengthened their hold of second spot, now sitting nine points clear with six matches remaining.
While the Bees and Swans both possess a game in hand, Watford require a maximum of 13 points during the run-in to book their spot back in the top tier.
Xisco's side remain on a seven-match unbeaten streak in the Championship, scoring 14 goals and conceding just three times at the opposite end of the pitch.
Winger Ismaila Sarr has netted twice in his last three appearances, taking his tally to 10 from 35 outings for the season.
Although they have remained in and around the playoff places throughout the campaign, Reading went into their last fixture against Derby County having failed to win in four matches.
With resurgent Bournemouth still possessing a game in hand, Reading will drop out of the top six if the Cherries take advantage of their extra fixture during the run-in.
Nevertheless, the drop off in form of Brentford and Swansea City has given hope to the chasing pack, particularly a Reading side which has now scored in eight successive contests.
Xisco could keep faith with the side which earned a draw at Middlesbrough, resisting the temptation to bring in fresh legs.
Having netted as a substitute against Derby, top goalscorer Lucas Joao is expected to be recalled to the Reading XI.
Watford possible starting lineup:
Bachmann; Femenia, Troost-Ekong, Sierralta, Masina; Chalobah, Hughes, Zinckernagel; Sarr, Pedro, Sema
Reading possible starting lineup:
Cabral; Yiadom, Holmes, Moore, Gibson; Rinomhota, Laurent; Meite, Olise, Ejaria; Joao
We say: Watford 2-1 Reading
Despite dropping points in the North-East, Xisco may feel that the disappointment could prove to be a blessing in disguise. With extra motivation ahead of this contest, we expect the Hornets to return to winning ways, potentially by the odd goal in three.
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