Spezia went down 2-1 to Inter Milan on the weekend, while Genoa conceded two goals without reply away to Benevento, which proved to be the final nail in the coffin for Rolando Maran who was then sacked on Monday.
Italiano will be pinpointing their defensive frailties as an area for improvement given that his side have kept a clean sheet on only three occasions in Serie A this season while conceding two or more goals in the other 10 matches.
In fact, no side has managed a higher such tally in the top five European leagues this season.
The Spezia manager will also be conscious of his side's dire home form which is the joint worst in the league this season, next to Torino's.
Genoa's loss to Benevento was Maran's last match in charge after it was announced on Monday that he and the club would part ways.
Genoa have been on a torrid run of form, having won none of their last 12 Serie A matches, and now find themselves well and truly in a relegation battle.
It has been widely reported that Davide Ballardini will return to manage Genoa for the fourth time in his managerial career.
Across that time, Ballardini has achieved an average points ratio of 1.38 across the 78 Serie A games that he has been in charge.
Ballardini's first task will be to make sure his side avoid losing two consecutive games against newly-promoted sides in a single top-flight season for the first time since April 2016, as they travel to relegation rivals, Spezia.
The new manager will hope to draw inspiration from Genoa's strong track record against Spezia that has seen them win four, and lose only once to the Serie A newcomers.
Spezia Serie A form: DDLLDL
Spezia form (all competitions): WDLLDL
Genoa Serie A form: LLDLDL
Genoa form (all competitions): WLDLDL
Valon Behrami is expected to come back into the starting XI after having to settle for the substitutes' bench in recent weeks.
To compound Genoa's woes, Ballardini will be without many of their key players, with what has become an extensive injury list.
Spezia possible starting lineup:
Provedel; Ferrer, Chabot, Erlic, Bastoni; Pobega, Ricci, Estevez; Gyasi, Nzola, Farias
Genoa possible starting lineup:
Perin; Goldaniga, Bani, Masiello, Pellegrini; Ghiglione, Lerager, Sturaro, Pjaca; Shomurodov, Destro
We say: Spezia 0-1 Genoa
There will not be much between these two sides on the day, but we could well see the boost of having a new manager at the helm make a real difference, and that is why we are predicting a narrow Genoa win.