Mainz will be looking for an immediate response after last week's disappointment but may not find it easy against a side fighting for their lives.
There have been just 16 goals in the last 10 meetings between the sides, and Schalke remain the league's lowest scorers so may struggle, especially on the road.
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Data Analysis
Our analysis of all available data, including recent performances and player stats up until an hour before kickoff, suggested the most likely outcome of this match was a Mainz 05 win with a probability of 54.76%. A win for Schalke 04 had a probability of 23.17% and a draw had a probability of 22.1%.
The most likely scoreline for a Mainz 05 win was 2-1 with a probability of 9.79%. The next most likely scorelines for that outcome were 1-0 (8.53%) and 2-0 (8.25%). The likeliest Schalke 04 win was 1-2 (6.01%), while for a drawn scoreline it was 1-1 (10.12%). The actual scoreline of 2-3 was predicted with a 2.3% likelihood.