The distraction of Liverpool's visit to the Etihad in a week's time cannot creep into the minds of Man City's XI here, but another mammoth encounter with a somewhat depleted defence is not a cause for optimism.
Simeone's Atletico have been nothing if not resilient when at their best - Man United found that out well enough - and with Simeone having almost all of his big-hitters available, we can envisage the in-form Colchoneros holding Guardiola's men to a score draw before the return leg in the Spanish capital.
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Data Analysis
Our analysis of all available data, including recent performances and player stats up until an hour before kickoff, suggested the most likely outcome of this match was a Manchester City win with a probability of 50.01%. A win for Atletico Madrid had a probability of 28.66% and a draw had a probability of 21.3%.
The most likely scoreline for a Manchester City win was 2-1 with a probability of 9%. The next most likely scorelines for that outcome were 3-1 (6.14%) and 2-0 (5.93%). The likeliest Atletico Madrid win was 1-2 (6.67%), while for a drawn scoreline it was 1-1 (8.79%). The actual scoreline of 1-0 was predicted with a 5.8% likelihood. Our data analysis correctly predicted that Manchester City would win this match.